Saturday 8 September 2018

Using patient's shared collective knowledge on the bedside

(RB) - Case:- The patient is complaining of a burning sensation in the lower limbs and around the face after taking warfarin tablet, After how much time of taking the warfarin tablet? He took the tablet at around 2 in the afternoon. Complaining of burning sensation since 1/2 hour and It appears to be a known side effect with many patients sharing their experiences about it

The patient's shared collective knowledge  https://treato.com/Warfarin,Burning/?a=s


(Avi)
Background:- 
Consider a warfarin sensitivity test. A significant number of people who take warfarin are at a higher risk of bleeding because their genes make them more sensitive to warfarin. If a family member experienced side effects from warfarin, talk to your doctor about taking a genetic warfarin sensitivity test. The test can determine if you have the genes that can increase your risk of bleeding.
What drugs and supplements can interact with warfarin?
Like any other medication, warfarin can interact with foods, other drugs, vitamins or herbal supplements. The interaction might lower the effectiveness of warfarin or increase your risk of bleeding. More than 120 drugs and foods that can interact with warfarin have been identified.

Drugs that can interact with warfarin include:

Many antibiotics
Antifungal medications, such as fluconazole (Diflucan)
Aspirin or aspirin-containing products
Ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve, Anaprox)
Acetaminophen (Tylenol, others) or acetaminophen-containing products
Cold or allergy medicines
Medications that treat abnormal heart rhythms, such as amiodarone (Amiodarone HCl, Pacerone)
Antacids or laxatives
Many other medications interact with warfarin. Be sure to tell your doctor or pharmacist that you take warfarin.

Supplements that can interact with warfarin include:

Coenzyme Q10 (Ubiquinone)
Dong quai
Garlic
Ginkgo biloba
Ginseng
Green tea
St. John's wort
Vitamin E
Many other supplements can interact with warfarin. Be sure to tell your health care provider about any supplements you take.

What foods and drinks might interact with warfarin?
Foods and drinks that might interact with warfarin include:

Cranberries or cranberry juice
Alcohol
Foods that are high in vitamin K, such as soybean and canola oils, spinach and broccoli
Garlic
Black licorice
Your doctor might recommend keeping the level of vitamin K in your diet consistent rather than avoiding vitamin K-rich foods altogether.

Note:- Burning is not a common side effect though

Discussion:- warfarin taken, post lunch, maybe one hour later.

An important patient experience shared on above link "Please, please do not panic, there is no need for it.

If you are taking warfarin, make sure you take it in the middle of a meal. I used to have the burning that you mention and solved this by taking my warfarin mid breakfast. If you are sensitive to it and take it before bed time on an empty stomach it will cause the burning.

Secondly warfarin will help prevent you from having a stroke - Its a lifesaver.... ... .."


Comment:- doctors may know less than expert patients about patient problems and possible solutions ( if the patients share the same problems).

Concusion:- initially i thought it may be a good advice to take warfarin during mid of meals, but i didn't had answer that why it will work and won't harm?.. just kept thinking and came to this answer.. maybe because taking it in mid of food/meal means..less/slow absorption & so less bioavailability, so less side effect but less efficacy too, and not a good advice for patient getting care.

will update more on it after some more research and finding a suitable solution for the burning sensation problem of the current patient. This is the first time I tried to take expert patient advice (though crowdsource data is not most authentic) for a patient getting care in real-time on bedside + opd for helping patient under care as a student researcher.

-Avinash Kumar
3rd Year MBBS
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